In depth analysis and explanation of retrospective and prospective molecular biotechnology methods. Most often utilized physiological models employed in the laboratory. Up-to-date education regarding medical laboratory analysis and interpretation of patient results. Medical pathophysiology of disease broken down into its respective pathological state and normal physiological mode.
Bilirubin is a metabolite of heme. It serves as a means to excrete unwanted heme, which is derived from various heme-containing proteins such as hemoglobin, myoglobin, and various P450 enzymes. Bilirubin is also notable for providing the color to bile, stool, and to a lesser extent the urine. Its produced by a two-stage reaction that … Continue reading Bilirubin Metabolism
Ketosis is a metabolic state in which the bodies energy supply comes from ketone bodies in the blood in contrast to a state of glycolysis in which there is adequate glucose breakdown. In most cases, ketosis results from a high metabolism of fatty acids which are converted to ketone bodies. Ketone bodies are formed from … Continue reading Ketosis and Ketoacidosis
Daratumumab (Darzalex) is an IgG1k monoclonal antibody directed against CD38, which is over expressed on the plasma cells in patients with multiple myeloma. Daratumumab binds to CD38 and causes apoptosis through antibody-dependent cellular cytotoxicity or complement-dependent cytotoxicity. In 2015 the FDA approved daratumumab for the treatment of refractory multiple myeloma. Refractory meaning that patients have … Continue reading DARA-T Workup
This article will review basic immunology principles by defining key terms and explaining different techniques and phenomenons. Key Definitions Sensitization is the basic reaction of an antigen and an antibody binding. During an antigen:antibody reaction, the antigen or the antibody can be measured using a variety of methods. Each method has its advantages and disadvantages. … Continue reading The Precipitation Curve